abstract：:Providing evidence-based interventions for infants and children is important in paediatric intensive care, where decision making impacts most acutely on morbidity and mortality. However, despite the major progress of medicine in the 21st century, we still lack this evidence for majority of the decisions we make. In th...

journal_title：Archives of disease in childhood

authors： Kanthimathinathan HK,Scholefield BR

更新日期：2014-11-01 00:00:00

abstract：:Cystic fibrosis is a disease that still causes a reduced life expectancy. The treatment burden remains high for affected individuals with often a combination of multiple oral and inhaled medications, as well as physiotherapy, required on a daily basis. In this article, we look at an overview of the pathogenesis, how t...

journal_title：Archives of disease in childhood

authors： Davies JC,Ebdon AM,Orchard C

更新日期：2014-11-01 00:00:00

abstract：:During the last half century there has been an exponential increase in international travel including to more exotic and long-haul destinations. The assessment of febrile returning child travellers presents diagnostic challenges and is often performed poorly. A detailed travel and medical history, clinical examination...

journal_title：Archives of disease in childhood

authors： Halbert J,Shingadia D,Zuckerman JN

更新日期：2014-10-01 00:00:00

abstract：:The past year has produced several new clinical guidelines germane to paediatric dermatology, as well as important work related to rheumatologic overlap disorders, psoriasis comorbidities, pigmented lesions and quality of life impact. This review highlights common diagnoses and treatments useful for the practicing pae...

journal_title：Archives of disease in childhood

authors： Khorsand K,Sidbury R

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:To review the work of one tertiary paediatric palliative care service in facilitating planned withdrawal of ventilatory support outside the intensive care setting, with the purpose of developing local guidance for practice. METHODS:Retrospective 10-year (2003-2012) case note review of intensive care patients...

journal_title：Archives of disease in childhood

authors： Laddie J,Craig F,Brierley J,Kelly P,Bluebond-Langner M

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:To prospectively examine relations between maternal DSM-IV-TR anxiety and depressive disorders and excessive infant crying. METHODS:Based on the prospective longitudinal Maternal Anxiety in Relation to Infant Development Study, n=306 expectant mothers were enrolled during early pregnancy and repeatedly intervi...

journal_title：Archives of disease in childhood

authors： Petzoldt J,Wittchen HU,Wittich J,Einsle F,Höfler M,Martini J

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Respiratory viral infections precipitate exacerbations of chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease though similar data in non-cystic fibrosis (CF) bronchiectasis are missing. Our study aimed to determine the point prevalence of viruses associated with exacerbation...

journal_title：Archives of disease in childhood

authors： Kapur N,Mackay IM,Sloots TP,Masters IB,Chang AB

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Mauriac syndrome is characterised by growth failure, cushingoid appearance and hepatomegaly which occurs in patients with insulin dependent diabetes and was first described shortly after the introduction of insulin as a treatment for the condition. OBJECTIVE:To describe the clinical features, histological f...

journal_title：Archives of disease in childhood

authors： Fitzpatrick E,Cotoi C,Quaglia A,Sakellariou S,Ford-Adams ME,Hadzic N

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:Sport practice is widely encouraged, both in guidelines and in clinical practice, because of its broad range of positive effects on health. However, very limited evidence directly supports this statement among adolescents and the sport duration that we should recommend remains unknown. We aimed to determine s...

journal_title：Archives of disease in childhood

authors： Merglen A,Flatz A,Bélanger RE,Michaud PA,Suris JC

更新日期：2014-03-01 00:00:00

abstract：:Reflection has become established as a key principle underpinning maintenance of standards within professional education and practice. A requirement to evidence reflection within performance review is intended to develop a transformative approach to practice, identify developmental goals, and ultimately, improve healt...

journal_title：Archives of disease in childhood

authors： Murdoch-Eaton D,Sandars J

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Mentoring is important for personal and professional development of doctors. Peer mentoring is a core skill in the UK paediatric postgraduate curriculum. However, there is a paucity of peer mentoring programmes aimed at postgraduate doctors in training (postgraduate trainees), and there are no such schemes w...

journal_title：Archives of disease in childhood

authors： Eisen S,Sukhani S,Brightwell A,Stoneham S,Long A

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Outcome of children with intestinal failure (IF) has improved on treatment with parenteral nutrition (PN). The effects of PN and IF on body composition (BC) are unknown. The aim was to review BC in PN-treated children and those weaned off and to compare with reference data. DESIGN:Children on long-term/home ...

journal_title：Archives of disease in childhood

authors： Pichler J,Chomtho S,Fewtrell M,Macdonald S,Hill S

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVES:To describe the clinical presentation and sequelae, including salt-wasting crises of newly-diagnosed congenital adrenal hyperplasia (CAH) in children aged over 1 year in a contemporary population without screening. To appraise the potential benefit of newborn screening for late-presenting CAH. DESIGN:Active...

journal_title：Archives of disease in childhood

authors： Knowles RL,Khalid JM,Oerton JM,Hindmarsh PC,Kelnar CJ,Dezateux C

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To investigate the accuracy of morphine infusions prepared for neonates in relation to the label strength and to identify the differences in deviation between infusions made in neonatal intensive care unit (NICU) and those dispensed ready-to-use from pharmacy. METHODS:Unused portions of morphine solution for...

journal_title：Archives of disease in childhood

authors： Aguado-Lorenzo V,Weeks K,Tunstell P,Turnock K,Watts T,Arenas-Lopez S

更新日期：2013-12-01 00:00:00

abstract：:Respiratory disease is a common cause of morbidity and mortality in children with Down's syndrome (DS). Causes range from those problems common to many children with DS, such as a narrow airway or impaired immunity, to rare structural lesions, such as tracheal bronchus. Additionally, other organ systems or extrinsic f...

journal_title：Archives of disease in childhood

authors： Watts R,Vyas H

更新日期：2013-10-01 00:00:00

abstract：:Rapid urbanisation in the 20th century has been accompanied by the development of slums. Nearly one-third of the world's population and more than 60% of urban populations in the least developed countries live in slums, including hundreds of millions of children. Slums are areas of broad social and health disadvantage ...

journal_title：Archives of disease in childhood

authors： Unger A

更新日期：2013-10-01 00:00:00

abstract：:The revised BSPGHAN guidelines for the diagnosis and management of coeliac disease represent an important shift in diagnostic strategy, aimed at simplifying and shortening the diagnostic process in selected cases. Guidance is given concerning the indications for testing for coeliac disease, which is still significantl...

journal_title：Archives of disease in childhood

authors： Murch S,Jenkins H,Auth M,Bremner R,Butt A,France S,Furman M,Gillett P,Kiparissi F,Lawson M,McLain B,Morris MA,Sleet S,Thorpe M,BSPGHAN.

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVES:To determine long-term seroprotection after serogroup C meningococcal (MenC) vaccination at the age of 9-12 years, with or without booster vaccination at the age of 13-15 years. DESIGN:Observational cohort study; follow-on from randomised study. SETTING:Participants were recruited from English secondary sc...

journal_title：Archives of disease in childhood

authors： de Whalley PC,Snape MD,Plested E,Thompson B,Nuthall E,Omar O,Borrow R,Pollard AJ

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Morbidity and mortality remain high following infant cardiac arrest. Optimal cardiopulmonary resuscitation (CPR) is therefore imperative. OBJECTIVE:Comparison of two-thumb (TT) and two-finger (TF) infant chest compression technique compliance with international recommendations. DESIGN:Randomised cross-over...

journal_title：Archives of disease in childhood

authors： Martin PS,Kemp AM,Theobald PS,Maguire SA,Jones MD

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:The mode of delivery has recently gained attention as another potential perinatal risk factor for childhood obesity but results are conflicting. OBJECTIVE:To examine whether caesarean section is independently associated with childhood obesity after adjusting for a broad range of confounding factors. METHOD...

journal_title：Archives of disease in childhood

authors： Flemming K,Woolcott CG,Allen AC,Veugelers PJ,Kuhle S

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:To describe the prevalence of depression in children with chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) and investigate the relationship between depression in CFS/ME and clinical symptoms such as fatigue, disability, pain and school attendance. DESIGN:Cross-sectional survey data using the Hos...

journal_title：Archives of disease in childhood

authors： Bould H,Collin SM,Lewis G,Rimes K,Crawley E

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:The development, delivery and evaluation of a training programme for medical and nursing professionals on best practice for informing families of their child's disability. DESIGN:A 2 h training course on 'Best practice guidelines for informing families of their child's disability' was designed based on the f...

journal_title：Archives of disease in childhood

authors： Harnett A,Bettendorf E,Tierney E,Guerin S,O'Rourke M,Hourihane JO

更新日期：2013-06-01 00:00:00

abstract：:Travel for the purposes of obtaining medical treatment is increasing, but very little is known about the extent or nature of child medical travel. This paper discusses the outcome of a systematic search for academic literature on paediatric medical travel, outlines the potential significance of 'return health migratio...

journal_title：Archives of disease in childhood

authors： Culley L,Hudson N,Baldwin K,Lakhanpaul M

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:It is often assumed that prolonged time to diagnosis (TTD) for cancer negatively influences overall survival and survivorship through advanced stage disease at diagnosis. This systematic review assesses existing early diagnosis research in childhood and young adult cancer and aims to identify whether a consensu...

journal_title：Archives of disease in childhood

authors： Lethaby CD,Picton S,Kinsey SE,Phillips R,van Laar M,Feltbower RG

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:Asians have a smaller muscle mass and a larger fat mass at the same body mass index (BMI) than most other ethnic groups. Due to a resulting higher cardiometabolic risk, the BMI cut-offs for overweight and obesity were lowered for adults. For Asian children universal criteria apply. The objectives of this stu...

journal_title：Archives of disease in childhood

authors： de Wilde JA,Zandbergen-Harlaar S,van Buuren S,Middelkoop BJ

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION:Wiskott-Aldrich syndrome (WAS) is an X-linked primary immunodeficiency caused by a mutation of the WAS protein gene. This protein actively participates in important cellular processes, and its presence is related to diverse clinical manifestations, including cutaneous alterations. The classical triad of WA...

journal_title：Archives of disease in childhood

authors： Loyola Presa JG,de Carvalho VO,Morrisey LR,Bonfim CM,Abagge KT,Vasselai A,Marinoni LP

更新日期：2013-04-01 00:00:00

abstract：:Pharmacogenomics research is becoming more prevalent in both academia and the pharmaceutical industry. While some discoveries have been integrated into practice and are benefiting patient care, these successes have been limited given the vast amount of research undertaken. However, the advances in high-throughput geno...

journal_title：Archives of disease in childhood

authors： Hawcutt DB,Thompson B,Smyth RL,Pirmohamed M

更新日期：2013-03-01 00:00:00

abstract：:Approximately 90% of children with cancer reside in low-income and middle-income countries (LMIC) where healthcare resources are scarce and allocation decisions difficult. The cost effectiveness of treating childhood cancers in these settings is unknown. The objective of the present work was to determine cost-effectiv...

journal_title：Archives of disease in childhood

authors： Bhakta N,Martiniuk AL,Gupta S,Howard SC

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:To describe the significance of pericardial effusion (PE), mitral regurgitation (MR) and impaired systolic function in predicting coronary artery lesions (CAL) at diagnosis and follow-up in Kawasaki disease (KD). DESIGN:Echocardiographic records on admission, at 1-3 weeks of illness, and at 6-8 weeks of illn...

journal_title：Archives of disease in childhood

authors： Lega JC,Bozio A,Cimaz R,Veyrier M,Floret D,Ducreux C,Reix P,Di Filippo S

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVES:To establish the incidence of childhood coeliac disease (CD) in Scotland between 1 September 2009 and 31 August 2010, to determine clinical features at presentation and reasons for diagnosis, and to identify any differences in incidence and practice between regions. DESIGN:Prospective data collection throug...

journal_title：Archives of disease in childhood

authors： White LE,Bannerman E,McGrogan P,Kastner-Cole D,Carnegie E,Gillett PM

更新日期：2013-01-01 00:00:00

abstract：AIM:To explore the variation in hospital admission rates and duration of inpatient stay across England. METHODS:Hospital Episode Statistics were used to identify all children aged below 2 years who were discharged from hospital with a primary code of bronchiolitis in England, between 1 April 2007 and 31 March 2010; ra...

journal_title：Archives of disease in childhood

authors： Cheung CR,Smith H,Thurland K,Duncan H,Semple MG

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:To determine risk factors for childhood overweight that can be identified during the first year of life to facilitate early identification and targeted intervention. DESIGN:Systematic review and meta-analysis. SEARCH STRATEGY:Electronic database search of MEDLINE, EMBASE, PubMed and CAB Abstracts. ELIGIBIL...

journal_title：Archives of disease in childhood

authors： Weng SF,Redsell SA,Swift JA,Yang M,Glazebrook CP

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Sodium phenylbutyrate (NaPB) is used as a treatment for urea cycle disorders (UCD). However, the available, licensed granule form has an extremely bad taste, which can compromise compliance and metabolic control. OBJECTIVES:A new, taste-masked, coated-granule formulation (Luc 01) under development was chara...

journal_title：Archives of disease in childhood

authors： Guffon N,Kibleur Y,Copalu W,Tissen C,Breitkreutz J

更新日期：2012-12-01 00:00:00

abstract：:Clinical trials in children in resource-poor environments are essential for local health policy and practice to be relevant and evidence based. Research must be ethical, appropriate, relevant and of good quality. It should, where possible, benefit the subjects studied,the clinical, scientific and support staff involve...

journal_title：Archives of disease in childhood

authors： Molyneux E,Mathanga D,Witte D,Molyneux M

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:There is a body of published research on the effectiveness of home visiting for the prevention of child maltreatment, but little in the peer reviewed literature on cost-effectiveness or value to society. The authors sought to determine the cost-effectiveness of alternative home visiting programmes to inform p...

journal_title：Archives of disease in childhood

authors： Dalziel K,Segal L

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:To evaluate whether dual energy x-ray absorptiometry (DXA) and quantitative ultrasound (QUS) classify the same children as 'abnormal' (SD (z) score (SDS) ≤-2). METHODS:Speed of sound (SOS) was measured at the radius and tibia using QUS and lumbar spine bone mineral density (BMD) using DXA in 621 subjects age...

journal_title：Archives of disease in childhood

authors： Williams JE,Wilson CM,Biassoni L,Suri R,Fewtrell MS

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:To describe the epidemiology of pedestrian road traffic injury in Lima and to identify associated child-level, family-level, and school travel-related variables. DESIGN:Case-control study. SETTING:The Instituto Nacional de Salud del Niño, the largest paediatric hospital in the city. PARTICIPANTS:Cases were...

journal_title：Archives of disease in childhood

authors： Pernica JM,LeBlanc JC,Soto-Castellares G,Donroe J,Carhuancho-Meza BA,Rainham DG,Gilman RH

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:In cystic fibrosis (CF), problems with sleep, eating/mealtime behaviours, physiotherapy adherence and parental mental health issues are common, yet their natural history and the extent of service use to address them are unknown. OBJECTIVE:Follow up the 2007 cohort to determine: (1) prevalence of child sleep...

journal_title：Archives of disease in childhood

authors： Sheehan J,Massie J,Hay M,Jaffe A,Glazner J,Armstrong D,Hiscock H

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:Antibiotic drugs are frequently used for viral infections in children. It is probable that health beliefs and parental concern have great influence on the use of drugs in children. This study, performed in The Netherlands, investigates whether the use of antibiotics in children is associated with the use of m...

journal_title：Archives of disease in childhood

authors： de Jong J,Bos JH,de Vries TW,de Jong-van den Berg LT

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Phenobarbital (PB), commonly used as the preferred treatment for neonatal seizure, is a drug that requires careful dose adjustments based on therapeutic drug monitoring. It has been reported that PB metabolism was affected by cytochrome P450 (CYP)2C19 polymorphisms in adults requiring dose adjustment. AIM:T...

journal_title：Archives of disease in childhood

authors： Lee SM,Chung JY,Lee YM,Park MS,Namgung R,Park KI,Lee C

更新日期：2012-06-01 00:00:00